The Neuroscience of Negative Thinking

Geral T. Blanchard • Jul 25, 2022

Passages in this handout are taken from Words Can Change Your Brain (2016) by Andrew Newberg, M.D., who has written many other highly acclaimed books on the brain.

This work incorporates mindfulness (thinking about your thinking) and analyzes communication patterns in yourself and with others. He writes:

The moment a person expresses even the slightest degree of negativity, it increases negativity in both the speaker’s and the listener’s brain. Instead of getting rid of anger by voicing it [as counselors often recommend], we actually increase it, and this can, over time, cause irreparable damage, not only to relationships, but to the brain as well. It can interfere with memory storage and cognitive accuracy.


What makes anger particularly dangerous is that it blinds you even to the fact that you’re angry; thus it gives you a false sense of certainty, confidence, and optimism.


Angry words send alarm messages through the brain, and they partially shut down the logic-and-reasoning centers located in the frontal lobes.


The more you stay focused on negative words and thoughts, the more you can actually damage key structures that regulate your memory, feelings, and emotions. You may disrupt your sleep, appetite, and the way your brain regulates happiness, longevity, and overall health.


The brain, it turns out, doesn’t distinguish between facts and fantasies when we color events with negativity. Instead, it assumes that a real danger exists in the world and unleashes potentially destructive brain chemicals, like cortisol.


Negative thinking is also self-perpetuating: the more you are exposed to it – your own or other peoples – the more your brain will generate additional negative feelings and thoughts. 


To make matters worse, the more emotional we get, the more real the imaginary thought becomes.

Just seeing a list of positive words for a few seconds will make a highly anxious or depressed person feel better, and people who use more positive words tend to have greater control over their emotional regulation.

The repetition of personally meaningful words can actually turn on stress-reducing genes. 


Negative words stimulate anxiety, and positive words can lower it. Studies consistently show that the brain gives more attention to negative words, even when we are not aware that we’ve heard them. This reinforces the argument that even the subtlest forms of negativity can sour relationships.


If you repetitiously focus on the word “peace,” saying it aloud or silently, you will begin to experience a sense of peacefulness in yourself and in others close to you. The thalamus will respond to this incoming message of peace, and it will relay the information to the rest of the brain.  Pleasure chemicals like dopamine will be released, the reward system of your brain will be stimulated, anxieties and doubts will fade away, and your entire body will relax. And if you do these practices consistently over a period of time, your sense of compassion will grow. In fact, some of the most recent studies show that this kind of exercise will increase the thickness of your neocortex and shrink the size of your amygdala, the flight-or-fight mechanism in your brain.


According to the Mayo Clinic, that followed seven thousand people over forty years, when you add optimistic thinking to your equation, you can actually add up to two years to your life.


When we are practicing what is most meaningful in our lives, we are less distracted by the problems that occur throughout the day.


Can a brief thirty second relaxation exercise really change your brain in ways that will measurably improve your communication skills? Yes! And several fMRI studies have shown that a one-minute relaxation exercise will increase activity in the cortex that really changes your brain in ways that will measurably improve your communication skills, social awareness, mood regulation, and improve decision making abilities. If you increase the length beyond one minute, additional parts of the brain will be activated that help you become more focused and attentive. Cortisol levels will drop, which means that your levels of biological stress will have decreased.


To build a new habit, we have to repeat a new behavior hundreds and hundreds of times. This is what a mindfulness practice can do for you.

Merely repeating positive affirmations to yourself may not raise mood or achievement very much. Instead you have to imbed optimism in your brain through the power of “non-negative thinking.”


Researchers at the University of Toledo show that by manipulating your own thoughts you can even undo negative memories and programming from a traumatic childhood by “rescripting” the events more accurately and imagining a different outcome or solution from this point onward.



As a shrewd Hasidic rabbi once said, “Before you speak, ask yourself this question, will your words improve the silence?”

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Geral Blanchard, LPC, is a psychotherapist who is university trained in psychology and anthropology. Formerly of Wyoming and currently residing in Iowa, Geral travels the world in search of ancient secrets that can augment the art and science of healing. From Western neuroscience to Amazonian shamanism, he has developed an understanding of how to combine old and new healing strategies to optimize recovery, whether from psychological or physical maladies.


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